Different hemagglutinin cleavage site variants of H7N7 in an influenza outbreak in chickens in Leipzig, Germany.
Identifieur interne : 000591 ( Main/Exploration ); précédent : 000590; suivant : 000592Different hemagglutinin cleavage site variants of H7N7 in an influenza outbreak in chickens in Leipzig, Germany.
Auteurs : C. Röhm [États-Unis] ; J. Süss ; V. Pohle ; R G WebsterSource :
- Virology [ 0042-6822 ] ; 1996.
Descripteurs français
- KwdFr :
- ADN viral (MeSH), Allemagne (épidémiologie), Animaux (MeSH), Données de séquences moléculaires (MeSH), Glycoprotéine hémagglutinine du virus influenza (MeSH), Grippe chez les oiseaux (virologie), Grippe chez les oiseaux (épidémiologie), Hémagglutinines virales (génétique), Hémagglutinines virales (métabolisme), Oies (MeSH), Phylogenèse (MeSH), Poulets (MeSH), Sous-type H7N7 du virus de la grippe A (MeSH), Séquence d'acides aminés (MeSH), Séquence nucléotidique (MeSH), Virus de la grippe A (génétique), Virus de la grippe A (métabolisme), Épidémies de maladies (médecine vétérinaire).
- MESH :
- génétique : Hémagglutinines virales, Virus de la grippe A.
- médecine vétérinaire : Épidémies de maladies.
- métabolisme : Hémagglutinines virales, Virus de la grippe A.
- virologie : Grippe chez les oiseaux.
- épidémiologie : Allemagne, Grippe chez les oiseaux.
- ADN viral, Animaux, Données de séquences moléculaires, Glycoprotéine hémagglutinine du virus influenza, Oies, Phylogenèse, Poulets, Sous-type H7N7 du virus de la grippe A, Séquence d'acides aminés, Séquence nucléotidique.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Amino Acid Sequence (MeSH), Animals (MeSH), Base Sequence (MeSH), Chickens (MeSH), DNA, Viral (MeSH), Disease Outbreaks (veterinary), Geese (MeSH), Germany (epidemiology), Hemagglutinin Glycoproteins, Influenza Virus (MeSH), Hemagglutinins, Viral (genetics), Hemagglutinins, Viral (metabolism), Influenza A Virus, H7N7 Subtype (MeSH), Influenza A virus (genetics), Influenza A virus (metabolism), Influenza in Birds (epidemiology), Influenza in Birds (virology), Molecular Sequence Data (MeSH), Phylogeny (MeSH).
- MESH :
- chemical , genetics : Hemagglutinins, Viral.
- chemical , metabolism : Hemagglutinins, Viral.
- chemical : DNA, Viral, Hemagglutinin Glycoproteins, Influenza Virus.
- geographic , epidemiology : Germany.
- epidemiology : Influenza in Birds.
- genetics : Influenza A virus.
- metabolism : Influenza A virus.
- veterinary : Disease Outbreaks.
- virology : Influenza in Birds.
- Amino Acid Sequence, Animals, Base Sequence, Chickens, Geese, Influenza A Virus, H7N7 Subtype, Molecular Sequence Data, Phylogeny.
Abstract
The hemagglutinin (HA) genes from four avian H7N7 influenza A isolates, from a single outbreak, were shown to possess different cleavage sites that contain varying numbers of basic amino acid residues (KKKKR, KRKKR, KKRKKR, KKKKKKR). All four variants are highly pathogenic in chickens and share an immediate common ancestral HA with A/tern/Potsdam/342-6/79 (H7N7) and A/swan/Potsdam/63-6/81 (H7N7). These viruses are nonpathogenic and contain no extra basic amino acids at the cleavage site of their HA. During evolution a common precursor virus acquired different sequences at the cleavage site of the HA and became highly pathogenic in chickens. In vitro assays revealed that the HA from A/chicken/Leipzig/79 with KKKKR at the cleavage site was only partially cleaved (41%), compared to 93-100% cleavage of the other HAs. Since all four viruses were highly pathogenic in chickens, these findings confirm that the degree of pathogenicity in vivo is not exclusively determined by the degree of HA cleavability.
DOI: 10.1006/viro.1996.0187
PubMed: 8615031
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Röhm</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38101, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38101</wicri:regionArea><wicri:noRegion>38101</wicri:noRegion></affiliation></author><author><name sortKey="Suss, J" sort="Suss, J" uniqKey="Suss J" first="J" last="Süss">J. Süss</name></author><author><name sortKey="Pohle, V" sort="Pohle, V" uniqKey="Pohle V" first="V" last="Pohle">V. Pohle</name></author><author><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R G" last="Webster">R G Webster</name></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><imprint><date when="1996" type="published">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term><term>Animals (MeSH)</term><term>Base Sequence (MeSH)</term><term>Chickens (MeSH)</term><term>DNA, Viral (MeSH)</term><term>Disease Outbreaks (veterinary)</term><term>Geese (MeSH)</term><term>Germany (epidemiology)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (MeSH)</term><term>Hemagglutinins, Viral (genetics)</term><term>Hemagglutinins, Viral (metabolism)</term><term>Influenza A Virus, H7N7 Subtype (MeSH)</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (metabolism)</term><term>Influenza in Birds (epidemiology)</term><term>Influenza in Birds (virology)</term><term>Molecular Sequence Data (MeSH)</term><term>Phylogeny (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral (MeSH)</term><term>Allemagne (épidémiologie)</term><term>Animaux (MeSH)</term><term>Données de séquences moléculaires (MeSH)</term><term>Glycoprotéine hémagglutinine du virus influenza (MeSH)</term><term>Grippe chez les oiseaux (virologie)</term><term>Grippe chez les oiseaux (épidémiologie)</term><term>Hémagglutinines virales (génétique)</term><term>Hémagglutinines virales (métabolisme)</term><term>Oies (MeSH)</term><term>Phylogenèse (MeSH)</term><term>Poulets (MeSH)</term><term>Sous-type H7N7 du virus de la grippe A (MeSH)</term><term>Séquence d'acides aminés (MeSH)</term><term>Séquence nucléotidique (MeSH)</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (métabolisme)</term><term>Épidémies de maladies (médecine vétérinaire)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinins, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hemagglutinins, Viral</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>DNA, Viral</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Germany</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Hémagglutinines virales</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Épidémies de maladies</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Hémagglutinines virales</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Disease Outbreaks</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe chez les oiseaux</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Allemagne</term><term>Grippe chez les oiseaux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Base Sequence</term><term>Chickens</term><term>Geese</term><term>Influenza A Virus, H7N7 Subtype</term><term>Molecular Sequence Data</term><term>Phylogeny</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ADN viral</term><term>Animaux</term><term>Données de séquences moléculaires</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Oies</term><term>Phylogenèse</term><term>Poulets</term><term>Sous-type H7N7 du virus de la grippe A</term><term>Séquence d'acides aminés</term><term>Séquence nucléotidique</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The hemagglutinin (HA) genes from four avian H7N7 influenza A isolates, from a single outbreak, were shown to possess different cleavage sites that contain varying numbers of basic amino acid residues (KKKKR, KRKKR, KKRKKR, KKKKKKR). All four variants are highly pathogenic in chickens and share an immediate common ancestral HA with A/tern/Potsdam/342-6/79 (H7N7) and A/swan/Potsdam/63-6/81 (H7N7). These viruses are nonpathogenic and contain no extra basic amino acids at the cleavage site of their HA. During evolution a common precursor virus acquired different sequences at the cleavage site of the HA and became highly pathogenic in chickens. In vitro assays revealed that the HA from A/chicken/Leipzig/79 with KKKKR at the cleavage site was only partially cleaved (41%), compared to 93-100% cleavage of the other HAs. Since all four viruses were highly pathogenic in chickens, these findings confirm that the degree of pathogenicity in vivo is not exclusively determined by the degree of HA cleavability.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8615031</PMID><DateCompleted><Year>1996</Year><Month>06</Month><Day>05</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0042-6822</ISSN><JournalIssue CitedMedium="Print"><Volume>218</Volume><Issue>1</Issue><PubDate><Year>1996</Year><Month>Apr</Month><Day>01</Day></PubDate></JournalIssue><Title>Virology</Title><ISOAbbreviation>Virology</ISOAbbreviation></Journal><ArticleTitle>Different hemagglutinin cleavage site variants of H7N7 in an influenza outbreak in chickens in Leipzig, Germany.</ArticleTitle><Pagination><MedlinePgn>253-7</MedlinePgn></Pagination><Abstract><AbstractText>The hemagglutinin (HA) genes from four avian H7N7 influenza A isolates, from a single outbreak, were shown to possess different cleavage sites that contain varying numbers of basic amino acid residues (KKKKR, KRKKR, KKRKKR, KKKKKKR). All four variants are highly pathogenic in chickens and share an immediate common ancestral HA with A/tern/Potsdam/342-6/79 (H7N7) and A/swan/Potsdam/63-6/81 (H7N7). These viruses are nonpathogenic and contain no extra basic amino acids at the cleavage site of their HA. During evolution a common precursor virus acquired different sequences at the cleavage site of the HA and became highly pathogenic in chickens. In vitro assays revealed that the HA from A/chicken/Leipzig/79 with KKKKR at the cleavage site was only partially cleaved (41%), compared to 93-100% cleavage of the other HAs. Since all four viruses were highly pathogenic in chickens, these findings confirm that the degree of pathogenicity in vivo is not exclusively determined by the degree of HA cleavability.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Röhm</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee, 38101, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Süss</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Pohle</LastName><ForeName>V</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Webster</LastName><ForeName>R G</ForeName><Initials>RG</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>AI-08831</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI-29680</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA-21765</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Virology</MedlineTA><NlmUniqueID>0110674</NlmUniqueID><ISSNLinking>0042-6822</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004279">DNA, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019267">Hemagglutinin Glycoproteins, 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MajorTopicYN="N">Geese</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019267" MajorTopicYN="N">Hemagglutinin Glycoproteins, Influenza Virus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006389" MajorTopicYN="N">Hemagglutinins, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053126" MajorTopicYN="Y">Influenza A Virus, H7N7 Subtype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005585" MajorTopicYN="N">Influenza in Birds</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1996</Year><Month>4</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1996</Year><Month>4</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1996</Year><Month>4</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8615031</ArticleId><ArticleId IdType="pii">S0042-6822(96)90187-7</ArticleId><ArticleId IdType="doi">10.1006/viro.1996.0187</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Pohle, V" sort="Pohle, V" uniqKey="Pohle V" first="V" last="Pohle">V. Pohle</name><name sortKey="Suss, J" sort="Suss, J" uniqKey="Suss J" first="J" last="Süss">J. Süss</name><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R G" last="Webster">R G Webster</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Rohm, C" sort="Rohm, C" uniqKey="Rohm C" first="C" last="Röhm">C. Röhm</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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